Oncrasin 1 is a small-molecule inhibitor primarily used in cancer research for its ability to selectively target and inhibit the growth of tumor cells with oncogenic mutations, particularly those involving H-Ras. It functions by binding to Rab GTPase family chaperones, disrupting protein trafficking and leading to the accumulation of misfolded proteins, activation of the cellular stress response pathway, and induction of apoptosis in dysregulated cancer cells. While downstream effects may involve pathways like IKK/NF-κB, its primary mechanism centers on Ras signaling disruption. This makes Oncrasin 1 a valuable tool for studying cell death mechanisms in Ras-driven cancers, exploring drug resistance, and identifying potential therapeutic targets for more selective anticancer agents.