Used as a small molecule inhibitor in biomedical research, specifically targeting the Wnt/β-catenin signaling pathway. This pathway is involved in cell proliferation, differentiation, and stem cell regulation, making iCRT-14 valuable in studying cancer development, particularly in colorectal and other Wnt-driven cancers. Researchers apply iCRT-14 in cellular and animal models to suppress oncogenic gene expression, helping to elucidate the role of β-catenin in tumor growth and to evaluate potential therapeutic strategies. Its use is primarily confined to preclinical research for cancer biology and drug discovery.