AM580 is a selective retinoid X receptor (RXR) agonist widely used in biomedical research to study nuclear receptor signaling pathways. It plays a key role in regulating gene expression involved in cell differentiation, proliferation, and apoptosis. Due to its specificity for RXR, it is used in studies related to cancer, particularly in models of leukemia, where it promotes differentiation of leukemic cells. It is also employed in metabolic and neurological research, including studies on insulin sensitivity, inflammation, and neurodegenerative diseases. Its ability to modulate transcription without activating retinoic acid receptors (RAR) makes it a valuable tool for dissecting RXR-specific effects in cellular and animal models.