Gambogic amide is primarily studied for its potent anticancer properties. It induces apoptosis in various cancer cell lines by targeting mitochondria and disrupting cellular redox balance. It shows activity against tumor cells resistant to conventional chemotherapy, making it a candidate for overcoming drug resistance. Research also indicates it inhibits the NF-κB signaling pathway, which plays a key role in inflammation and tumor progression. Due to its ability to suppress cell proliferation and induce cell death, gambogic amide is being explored as a lead compound in developing novel anticancer agents. Additionally, it has shown potential in inhibiting metastasis and angiogenesis in preclinical models.