YAP-TEAD-IN-1 TFA is primarily used in biomedical research to inhibit the interaction between YAP (Yes-associated protein) and TEAD (Transcriptional Enhanced Associate Domain) transcription factors. This inhibition is crucial in studying the Hippo signaling pathway, which plays a significant role in regulating cell proliferation, organ size, and tissue regeneration. By blocking YAP-TEAD binding, researchers can investigate the effects on cancer cell growth and survival, particularly in cancers where this pathway is dysregulated, such as mesothelioma, liver cancer, and breast cancer. Additionally, it serves as a valuable tool in developing potential therapeutic strategies targeting the Hippo pathway for cancer treatment.