(R)-GNE-140 is primarily researched for its potential in cancer therapy, particularly in targeting lactate dehydrogenase A (LDHA). LDHA plays a critical role in the metabolism of cancer cells, enabling them to thrive in low-oxygen environments. By inhibiting LDHA, (R)-GNE-140 disrupts the energy production of cancer cells, potentially slowing tumor growth and enhancing the effectiveness of other cancer treatments. Its application is being explored in preclinical studies, focusing on its ability to selectively target cancer cells while minimizing damage to healthy tissues. This makes it a promising candidate for combination therapies in oncology.