CREB inhibitor (666-15) is primarily used in research to study the role of the CREB (cAMP response element-binding) protein in cellular processes. It is applied in experiments to inhibit CREB-mediated transcription, which helps in understanding its involvement in gene expression, memory formation, and neuronal plasticity. This inhibitor is also utilized in cancer research to explore its potential in blocking CREB-dependent pathways that promote tumor growth and survival. Additionally, it aids in investigating CREB's role in metabolic regulation and its impact on diseases like diabetes and obesity. Its application extends to neurobiological studies, where it helps examine the effects of CREB inhibition on learning, memory, and mood disorders.