KN-93 phosphate is widely used in biochemical and pharmacological research as a selective inhibitor of calcium/calmodulin-dependent protein kinase II (CaMKII). Its primary application is in studying the role of CaMKII in various cellular processes, including signal transduction, memory formation, and cardiac function. Researchers utilize KN-93 phosphate to investigate the mechanisms underlying neurological disorders, such as Alzheimer's disease, and cardiovascular conditions, like arrhythmias and heart failure. Additionally, it is employed in experimental models to explore the involvement of CaMKII in inflammation, apoptosis, and cellular stress responses. By inhibiting CaMKII activity, KN-93 phosphate helps elucidate the enzyme's contributions to disease pathways and potential therapeutic targets.