Xestospongin C is primarily utilized in research settings as a selective inhibitor of inositol 1,4,5-trisphosphate (IP3) receptor channels. It is particularly valuable in studying calcium signaling pathways within cells, as it blocks the release of calcium from the endoplasmic reticulum. This property makes it a useful tool for investigating the role of IP3 receptors in various cellular processes, including neurotransmission, muscle contraction, and apoptosis. Additionally, Xestospongin C has been employed in studies exploring the mechanisms of diseases linked to calcium dysregulation, such as neurodegenerative disorders and cardiovascular conditions. Its application helps researchers better understand cellular communication and the impact of calcium signaling on physiological and pathological states.