Manidipine dihydrochloride is primarily used as a calcium channel blocker in the treatment of hypertension. It works by relaxing the blood vessels, which helps to lower blood pressure and improve blood flow. This makes it effective in managing high blood pressure and reducing the risk of cardiovascular complications such as strokes and heart attacks. Additionally, it is sometimes prescribed to patients with chronic kidney disease, as it can help protect kidney function by reducing pressure on the renal arteries. Its long-acting nature allows for once-daily dosing, improving patient compliance and maintaining consistent blood pressure control.