(R)-3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
95%
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description Product Description
This compound serves as a key chiral intermediate in the synthesis of dihydropyridine calcium channel blockers, such as amlodipine and related pharmaceuticals used in cardiovascular therapy. It is employed in the production of drugs effective against hypertension and angina by facilitating the construction of the 1,4-dihydropyridine core with specific substituents, including a 2-chlorophenyl group and a 2-((2-aminoethoxy)methyl) moiety. The (R)-enantiomer is preferred due to its higher stereoselectivity, leading to products with improved potency, selectivity for vascular tissues, and favorable pharmacokinetics suitable for sustained-release formulations. This intermediate supports long-term management of high blood pressure and prevention of myocardial ischemia while minimizing cardiac side effects.
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