Used primarily in the treatment of hypertension (high blood pressure). It belongs to the class of calcium channel blockers, which work by relaxing the blood vessels, allowing the heart to pump blood more easily. This helps reduce the risk of stroke, heart attack, and kidney problems associated with chronic high blood pressure. Nisoldipine is known for its potent vasodilatory effects, particularly on coronary and peripheral arteries, making it effective in managing angina in some cases. Due to its long duration of action, it is often administered once daily, improving patient compliance.