Ethyl 4-(3-Aminophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylate
≥95%
Reagent
Code: #171998
CAS Number
138135-48-5
blur_circular Chemical Specifications
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Molecular Information
Weight
330.38 g/mol
Formula
C₁₈H₂₂N₂O₄
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Registry Numbers
MDL Number
MFCD20491402
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Storage & Handling
Storage
Room temperature, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of calcium channel blockers, particularly dihydropyridine-based drugs. These compounds are widely employed in the treatment of cardiovascular diseases such as hypertension and angina due to their ability to selectively block L-type calcium channels in vascular smooth muscle. The presence of functional groups like ester and amine allows for further chemical modifications, enabling the development of novel derivatives with optimized pharmacokinetic and pharmacodynamic profiles. Also explored in medicinal chemistry for structure-activity relationship (SAR) studies to enhance potency and reduce side effects in next-generation cardiovascular agents.
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