Tris-EDTA-NaCl solution is widely used in molecular biology and biochemistry for various applications. It is commonly employed as a buffer in DNA and RNA extraction procedures, where it helps to stabilize nucleic acids and prevent degradation by nucleases. The solution is also utilized in cell lysis protocols to break open cells and release their contents while maintaining the integrity of the genetic material. Additionally, it is often used in electrophoresis techniques to prepare samples and running buffers, ensuring optimal conditions for the separation of DNA fragments. In immunohistochemistry, Tris-EDTA-NaCl solution can be used for antigen retrieval, enhancing the detection of target proteins in tissue samples. Its ability to chelate metal ions makes it valuable in processes where metal ion interference needs to be minimized.