Tris-EDTA buffer is widely used in molecular biology for DNA and RNA stabilization. It is commonly employed in DNA extraction and purification processes to prevent degradation by nucleases. The buffer is also utilized in gel electrophoresis to maintain the pH and integrity of nucleic acids during separation. Additionally, it is a key component in DNA storage, ensuring long-term stability by chelating metal ions that could otherwise catalyze degradation. In PCR and other enzymatic reactions, Tris-EDTA buffer helps maintain optimal conditions for enzyme activity and DNA integrity.