TAE Buffer is widely used in molecular biology for the electrophoresis of nucleic acids, particularly DNA and RNA. It is the preferred buffer for agarose gel electrophoresis due to its ability to maintain stable pH and provide optimal conditions for separating DNA fragments by size. TAE Buffer is also used in DNA staining techniques, as it is compatible with ethidium bromide and other fluorescent dyes. Additionally, it is employed in DNA extraction and purification processes, where it helps in maintaining the integrity of DNA during handling. Its low ionic strength makes it suitable for applications requiring high-resolution separation of DNA fragments. It is also utilized in preparing samples for genetic analyses such as PCR and DNA cloning.