The Sodium acetate-chloroacetic acid buffer (pH 3.0) is used in biochemical and analytical laboratories to maintain stable pH conditions around 3.0 during enzymatic reactions and electrophoresis under acidic environments. It effectively controls pH in the acidic range (approximately pH 2.8-3.2), making it suitable for specific DNA and protein handling procedures that require low pH, such as certain precipitation or separation techniques. This buffer is applied in specialized buffer systems for gel electrophoresis where low pH is critical for particular nucleic acid separations. It is also utilized in industrial processes requiring pH stabilization involving chloroacetic acid. The buffer's compatibility with biological systems supports its use in purification and extraction protocols for sensitive biomolecules at acidic pH.