Sucrose Gelatin Veronal Buffer with EDTA (SGVBE) is primarily used in biological and biochemical research for the preservation and stabilization of labile biological samples. It is particularly effective in maintaining the integrity of cellular structures and enzymes during experimental procedures. The buffer is commonly employed in the preparation of samples for electron microscopy, where it helps to prevent degradation and maintain the structural details of the specimens. Additionally, SGVBE is utilized in the isolation and purification of subcellular components, such as mitochondria and nuclei, ensuring their functionality and structural integrity. The inclusion of EDTA in the buffer aids in chelating metal ions, which can otherwise interfere with enzymatic activities and cause oxidative damage. This makes SGVBE a valuable tool in various biochemical assays and studies requiring precise control over the sample environment.