Triethylammonium acetate buffer is widely used in analytical chemistry, particularly in liquid chromatography-mass spectrometry (LC-MS) applications. Its volatile nature makes it an ideal choice for LC-MS, as it evaporates easily under vacuum, minimizing interference with the detection process. This buffer is also employed in the separation and analysis of biomolecules, such as peptides, proteins, and nucleic acids, due to its compatibility with both aqueous and organic solvents. Additionally, it is utilized in capillary electrophoresis for the efficient separation of charged molecules. Its ability to maintain stable pH levels in various experimental conditions further enhances its utility in biochemical and biophysical research.