FHD-286
99%
Reagent
Code: #189427
CAS Number
2671128-05-3
blur_circular Chemical Specifications
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Molecular Information
Weight
562.66 g/mol
Formula
C₂₄H₃₀N₆O₆S₂
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Storage & Handling
Storage
2-8°C
description Product Description
Used in the treatment of certain hematologic malignancies, particularly relapsed or refractory acute myeloid leukemia (AML) and higher-risk myelodysplastic syndromes (MDS). It functions as a potent and selective inhibitor of the chromatin remodeling protein BRD9, which plays a role in gene expression regulation within cancer cells. By targeting BRD9, it disrupts oncogenic transcriptional programs, leading to cancer cell death. Currently under clinical investigation in phase 1/2 trials to evaluate safety, dosing, and efficacy alone and in combination with other agents like venetoclax or hypomethylating drugs. Shows promise in patients who have limited response to standard therapies.
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