Phosphorus(V) oxybromide is primarily used as a brominating agent in organic synthesis. It is particularly effective in converting alcohols to alkyl bromides, which are valuable intermediates in the production of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it is employed in the synthesis of phosphorus-containing compounds, where it serves as a source of both phosphorus and bromine. Its reactivity makes it useful in the preparation of flame retardants and other specialty chemicals. In some cases, it is also utilized in the modification of polymers to enhance their properties. Due to its strong reactivity, it is handled with care in controlled environments to ensure safety and efficiency in chemical processes.