3,4-Difluorophenylboronic acid is widely used in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. This reaction is essential for forming carbon-carbon bonds, making it valuable in the production of pharmaceuticals, agrochemicals, and advanced materials.

In medicinal chemistry, it serves as a key intermediate for synthesizing compounds with potential therapeutic properties. Its ability to introduce fluorine atoms into molecules enhances their stability and bioavailability, which is crucial in drug development.

Additionally, it is employed in the creation of organic electronic materials, such as OLEDs and semiconductors, due to its role in constructing complex aromatic structures. Its versatility and efficiency in coupling reactions make it a valuable tool in both industrial and research settings.