2-(Pivalamido)phenylboronic acid is primarily utilized in organic synthesis, particularly in cross-coupling reactions such as Suzuki-Miyaura coupling. This reaction is widely employed in the pharmaceutical industry for the construction of biaryl compounds, which are key intermediates in the synthesis of various drugs and bioactive molecules. Its stability and reactivity make it a valuable reagent for creating complex organic structures.

Additionally, it is used in the development of sensors and molecular recognition systems due to its boronic acid group, which can selectively bind to diols and sugars. This property is exploited in glucose sensing and other biochemical applications, making it a crucial component in diagnostic tools and research. Its pivalamido group also enhances solubility and stability, further broadening its utility in diverse chemical processes.