Used as a stable and versatile reagent in Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of conjugated enynes and complex organic frameworks. Its MIDA (N-methyliminodiacetic acid) protecting group enhances stability and solubility, allowing for controlled, iterative coupling in multi-step syntheses. Particularly valuable in natural product synthesis and pharmaceutical development where precise alkyne incorporation is required. The ester’s air and moisture tolerance simplifies handling and improves shelf life compared to unprotected boronic acids.