2-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
98%
Reagent
Code: #160252
CAS Number
452972-11-1
blur_circular Chemical Specifications
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Molecular Information
Weight
239.51 g/mol
Formula
C₁₁H₁₅BClNO₂
thermostat
Physical Properties
Boiling Point
335.1°C
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Storage & Handling
Storage
2-8°C
description Product Description
Widely used in Suzuki-Miyaura cross-coupling reactions, this compound serves as a key building block for forming carbon-carbon bonds in pharmaceutical and agrochemical synthesis. Its boronate ester group readily reacts with aryl or heteroaryl halides in the presence of a palladium catalyst, enabling efficient construction of complex pyridine derivatives. It is particularly valuable in drug discovery for modifying heterocyclic scaffolds, improving potency, and optimizing pharmacokinetic properties. The stability and reactivity profile make it suitable for late-stage functionalization in multi-step synthetic routes.
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