tert-Butyl (1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclobutyl)carbamate
97%
Reagent
Code: #148624
CAS Number
1032528-06-5
blur_circular Chemical Specifications
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Molecular Information
Weight
373.29 g/mol
Formula
C₂₁H₃₂BNO₄
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Registry Numbers
MDL Number
MFCD18762017
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Storage & Handling
Storage
2-8°C, stored in inert gas
description Product Description
Used primarily as an intermediate in pharmaceutical synthesis, especially in Suzuki-Miyaura cross-coupling reactions to construct biaryl or aryl-heteroaryl frameworks. The boronate ester group enables efficient carbon-carbon bond formation under palladium catalysis, making it valuable for building complex organic molecules. Commonly employed in the development of active pharmaceutical ingredients (APIs) where cyclobutyl and aryl motifs are part of the target structure. The tert-butyl carbamate (Boc) group protects the amine during synthesis and can be removed selectively under acidic conditions, allowing for further functionalization downstream. Its stability and reactivity profile make it suitable for use in multi-step synthetic routes in medicinal chemistry.
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