Used as a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds in medicinal chemistry and drug development. Its rigid bicyclo[1.1.1]pentane core acts as a bioisostere for phenyl or tert-butyl groups, improving metabolic stability, solubility, and pharmacokinetic properties in pharmaceutical candidates. Commonly employed in late-stage functionalization of complex molecules, especially in the design of CNS-active drugs and agrochemicals. The boronate ester group allows for efficient and selective coupling under mild conditions, making it valuable in high-throughput synthesis and fragment-based drug discovery.