2,2,2-Trifluoro-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone
97%
Reagent
Code: #130754
CAS Number
1004294-77-2
blur_circular Chemical Specifications
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Molecular Information
Weight
300.08 g/mol
Formula
C₁₄H₁₆BF₃O₃
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Registry Numbers
MDL Number
MFCD16628195
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Physical Properties
Boiling Point
343.9±42.0 °C(Predicted)
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Storage & Handling
Density
1.20±0.1 g/cm3(Predicted)
Storage
2-8°C, sealed, dry
description Product Description
Used primarily as a key intermediate in Suzuki-Miyaura cross-coupling reactions, this compound enables the formation of carbon-carbon bonds in the synthesis of pharmaceuticals and agrochemicals. The presence of the trifluoromethyl ketone group adds electron-withdrawing character, which can influence reactivity and stability in drug-like molecules. Its boronate ester functionality allows for efficient coupling with aryl halides, making it valuable in medicinal chemistry for constructing biaryl systems found in bioactive molecules. It is also employed in the development of fluorinated analogs of lead compounds to improve metabolic stability and membrane permeability.
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