Trimethyl borate is widely used as a precursor in the synthesis of boron-containing compounds, particularly in the production of borate esters and other boron derivatives. It serves as a key reagent in organic synthesis, facilitating the introduction of boron into various molecules, which is essential for creating specialized materials like flame retardants and polymers.

In the field of electronics, it plays a role in the manufacturing of semiconductors and as a dopant in the production of specialty glasses and ceramics. Additionally, it is utilized as a solvent in certain chemical reactions and as a catalyst in esterification processes.

Trimethyl borate is also employed in the preparation of boron nitride, a material with high thermal and chemical stability, used in advanced industrial applications. Its ability to act as a cross-linking agent makes it valuable in the production of adhesives and coatings, enhancing their durability and performance.