Glycophorin, particularly glycophorin A, plays a crucial role in blood grouping and transfusion medicine. It is a key antigen on the surface of red blood cells, determining the MN blood group system. This system is essential for compatibility testing in blood transfusions, ensuring safe and effective donor-recipient matches. Additionally, glycophorin A is utilized in research to study cell membrane structure and function, as it is a major sialoglycoprotein that influences cell adhesion and signaling. Its interaction with pathogens, such as malaria parasites, is also a focus of biomedical studies, aiding in the development of therapeutic strategies against infectious diseases.