PAMAM dendrimers with an ethylenediamine core are widely used in drug delivery systems due to their unique structure and ability to encapsulate or bind therapeutic agents. Their highly branched, tree-like architecture allows for precise control over drug loading and release, making them ideal for targeted delivery to specific tissues or cells. In cancer therapy, they are employed to deliver chemotherapeutic drugs directly to tumor cells, minimizing damage to healthy tissues and improving treatment efficacy.

These dendrimers are also utilized in gene therapy as non-viral vectors for delivering genetic material, such as DNA or RNA, into cells. Their positive surface charge facilitates binding with negatively charged nucleic acids, enabling efficient cellular uptake and gene expression. This application holds promise for treating genetic disorders and developing advanced vaccines.

Additionally, PAMAM dendrimers are used in diagnostic imaging as contrast agents. Their ability to carry multiple imaging molecules enhances signal intensity, improving the accuracy of techniques like MRI or fluorescence imaging. They are also explored in biosensors for detecting biomolecules due to their high surface functionality and sensitivity.

In materials science, these dendrimers serve as nanoscale building blocks for creating advanced materials with tailored properties, such as coatings, catalysts, or nanocomposites. They are also applied in environmental remediation, such as removing toxins or heavy metals from water, due to their strong binding and adsorption capabilities. Their versatility and precision make them valuable across various scientific and industrial applications.