Estriol is widely used in hormone replacement therapy (HRT) to alleviate symptoms of menopause, such as hot flashes, vaginal dryness, and urinary discomfort. It is particularly favored for its mild estrogenic effects and lower risk of side effects compared to stronger estrogens. In gynecology, estriol is applied topically in creams or suppositories to treat atrophic vaginitis and improve vaginal health. It is also used in some formulations to support skin elasticity and hydration, making it a component in certain dermatological products. Additionally, estriol has been studied for its potential role in managing osteoporosis and supporting bone health in postmenopausal women. Its safety profile makes it a suitable option for short-term and localized treatments.