Progesterone is widely used in hormone replacement therapy (HRT) to alleviate symptoms of menopause, such as hot flashes, night sweats, and mood swings. It is often prescribed alongside estrogen to protect the uterine lining from hyperplasia, reducing the risk of endometrial cancer. In reproductive health, it plays a critical role in supporting pregnancy, particularly in assisted reproductive technologies (ART) like in vitro fertilization (IVF), where it helps prepare the uterus for embryo implantation and maintains early pregnancy. Additionally, it is used to treat menstrual disorders, such as irregular cycles or heavy bleeding, by regulating the hormonal balance. In some cases, it is also employed to manage conditions like endometriosis or to prevent preterm birth in high-risk pregnancies.