Diethylstilbestrol (DES) is a synthetic nonsteroidal estrogen historically used in various medical applications to treat conditions such as prostate cancer in men, advanced breast cancer in postmenopausal women, menopausal symptoms, and to prevent miscarriages. However, its use for preventing miscarriages and managing menopausal symptoms has been discontinued due to severe health risks, including increased cancer risk in users and offspring exposed in utero. In veterinary medicine, it was employed to promote growth in livestock and manage reproductive issues in animals, though this practice is now banned in many countries. Additionally, it has been utilized in hormone replacement therapies and research studies to understand estrogen-related mechanisms. Due to its carcinogenic potential and other adverse effects on human health, its use is heavily restricted worldwide.