Calcitriol is primarily used in the treatment of conditions related to calcium and phosphate metabolism. It is effective in managing hypocalcemia in patients with chronic kidney disease, particularly those undergoing dialysis, as it helps to increase calcium absorption in the intestines and promotes bone mineralization. Additionally, it is prescribed for individuals with hypoparathyroidism to maintain normal calcium levels. Calcitriol is also utilized in the management of osteoporosis, especially in postmenopausal women, to enhance bone density and reduce fracture risk. In some cases, it is applied topically to treat psoriasis, as it helps to regulate skin cell growth and differentiation.