Widely used in bioconjugation and chemical biology, this compound enables selective labeling and modification of biomolecules through SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry. Its sulfonyl fluoride group reacts efficiently with nucleophilic residues like lysine and tyrosine in proteins, allowing stable covalent linkage under physiological conditions. The boronate ester moiety facilitates palladium-catalyzed cross-coupling reactions, making it valuable in dual-functionalization strategies for constructing complex molecules. It is particularly useful in drug discovery, proteomics, and the development of covalent probes and targeted therapeutics. Its stability in ambient conditions and high selectivity enhance its utility in both in vitro and cellular environments.