1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (sodium salt)
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Used extensively in bioconjugation and drug delivery systems, this chemical enables the formation of disulfide bonds between liposomes and targeting molecules such as antibodies or peptides. Its pyridyldithiol group reacts selectively with thiol-containing compounds, allowing controlled attachment of biomolecules to lipid membranes. Commonly employed in the development of immunoliposomes, it helps deliver therapeutic agents specifically to diseased cells, such as cancer cells, enhancing treatment efficacy and reducing off-target effects. The disulfide linkage is cleavable under reducing conditions, like those found inside cells, enabling triggered release of encapsulated drugs. It is also utilized in surface immobilization techniques for biosensors and diagnostic platforms.
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