Used as a highly reactive chemical reagent in the synthesis of covalent inhibitors, particularly in pharmaceutical research. Its fluorosulfonyl and sulfamoyl fluoride groups enable selective and irreversible modification of proteins by targeting specific amino acid residues, such as lysine and tyrosine. Commonly employed in activity-based protein profiling (ABPP) to study enzyme function and identify potential drug targets. Also utilized in the development of chemical probes for detecting and labeling biomolecules in complex biological systems. Shows utility in fragment-based drug discovery due to its ability to form stable covalent bonds with biomacromolecules.