Angelicide is used primarily as a biocidal agent in water treatment systems. It prevents the growth of algae, fungi, and bacteria in industrial cooling towers, paper mills, and metalworking fluids. Its effectiveness in low concentrations makes it suitable for continuous dosing in closed-loop systems. It is also incorporated into coatings and paints to provide antimicrobial protection, especially in high-humidity environments. Due to its stability across a wide pH range, it remains active in diverse operational conditions. Angelicide is favored in applications where resistance development in microbes is a concern, as it disrupts multiple cellular targets, reducing the likelihood of microbial adaptation.