CU-CPT-8m is a selective agonist of the transient receptor potential melastatin 8 (TRPM8) ion channel, which is primarily involved in sensing cold temperatures. Its main application lies in research settings where it is used to study cold sensation and pain pathways. It helps investigate the role of TRPM8 in conditions such as cold allodynia, migraine, and neuropathic pain. Due to its ability to activate TRPM8 with high specificity, it is also used in screening assays for potential analgesic drugs. Additionally, CU-CPT-8m has been employed in studies exploring bladder dysfunction and prostate cancer, where TRPM8 activity may play a regulatory role. Its use enables targeted modulation of the channel without affecting other thermosensitive receptors, making it a valuable tool in sensory neuroscience and drug development.