Nesiritide is primarily used in the treatment of acute decompensated heart failure (ADHF). It works by mimicking the action of the body's natural brain natriuretic peptide (BNP), which helps to regulate blood pressure and fluid balance. The drug promotes vasodilation, reducing the workload on the heart by dilating veins and arteries, and enhances diuresis, helping to remove excess fluid from the body. This leads to improved symptoms such as shortness of breath and reduced fluid retention. Nesiritide is typically administered intravenously in a hospital setting under close medical supervision. It is particularly beneficial for patients who do not respond adequately to standard therapies like diuretics or vasodilators. However, its use is carefully monitored due to potential side effects, including hypotension and renal dysfunction. Overall, it serves as a critical therapeutic option for managing severe heart failure episodes.