Orexin A plays a critical role in regulating sleep-wake cycles and maintaining wakefulness. It is used in research to study narcolepsy and other sleep disorders, as deficiencies in orexin signaling are linked to these conditions. Additionally, it is investigated for its potential in treating insomnia and improving alertness in individuals with excessive daytime sleepiness. Orexin A is also explored in the context of appetite regulation and energy homeostasis, making it relevant in obesity and metabolic disorder studies. In neuroscience, it helps in understanding the mechanisms of addiction, stress, and mood regulation due to its influence on the brain's reward and arousal systems.