LL-37 amide is a naturally occurring antimicrobial peptide derived from human cathelicidin, known for its broad-spectrum activity against bacteria, viruses, and fungi. It plays a key role in innate immunity by disrupting microbial membranes and neutralizing pathogens. In biomedical research, it is studied for its potential in developing new antimicrobial therapies, especially against drug-resistant strains. It also promotes wound healing by stimulating cell migration and angiogenesis, making it valuable in dermatology and tissue engineering. Additionally, LL-37 amide modulates immune responses, showing promise in treatments for inflammatory diseases and as an adjuvant in vaccine development. Its ability to enhance immune cell recruitment and regulate inflammation supports ongoing exploration in immunotherapy and regenerative medicine.