Apelin-13 is a bioactive peptide involved in regulating cardiovascular function, making it a target of interest in heart disease research. It activates the APJ receptor, promoting vasodilation and improving cardiac contractility, which can be beneficial in conditions like heart failure. Studies suggest it may enhance fluid balance and reduce blood pressure, offering potential in treating hypertension and pulmonary arterial hypertension. In metabolic research, Apelin-13 shows insulin-sensitizing effects, supporting its role in glucose uptake and energy metabolism, which could be useful in managing type 2 diabetes. It also plays a part in angiogenesis, aiding tissue repair and wound healing, particularly in ischemic conditions where blood flow is compromised. Emerging evidence points to neuroprotective properties, with possible applications in stroke and neurodegenerative diseases due to its ability to cross the blood-brain barrier and modulate central nervous system functions. Additionally, Apelin-13 is being explored for its role in inflammation and immune regulation, suggesting therapeutic potential in chronic inflammatory conditions. Due to its short half-life, research focuses on developing stable analogs or delivery methods to harness its effects in clinical settings.