12-HETE plays a significant role in various physiological and pathological processes. It is involved in inflammation and immune responses, where it acts as a signaling molecule to mediate cellular interactions. In cancer research, 12-HETE is studied for its role in tumor progression and angiogenesis, as it promotes the growth and survival of cancer cells. It also contributes to vascular functions, influencing blood vessel constriction and dilation. Additionally, 12-HETE is implicated in skin disorders, such as psoriasis, due to its involvement in keratinocyte proliferation and differentiation. Its role in oxidative stress and tissue injury further highlights its importance in disease mechanisms.