13,14-Dihydro-15-keto-tetranor Prostaglandin E2 is the principal urinary metabolite of Prostaglandin E2 (PGE2) and is biologically inactive. It is primarily used in medical and biochemical research as a stable biomarker to quantify endogenous PGE2 production in vivo. This compound is employed in immunoassays, radioimmunoassays, and other analytical methods to study prostaglandin metabolism, inflammation, renal function, and related physiological processes, aiding in the understanding of diseases involving eicosanoid pathways.