13(S)-HOTrE is primarily used in research settings to study its role in inflammatory processes and cellular signaling. It is investigated for its potential anti-inflammatory properties, particularly in conditions like arthritis and cardiovascular diseases. Researchers explore its effects on lipid metabolism and its ability to modulate enzymes such as lipoxygenases. Additionally, it is studied for its impact on oxidative stress and its potential therapeutic applications in chronic inflammatory disorders. Its role in the biosynthesis of specialized pro-resolving mediators (SPMs) is also a key area of interest, as these compounds help resolve inflammation and promote tissue repair.