15(S)-HETrE is a bioactive lipid mediator primarily used in biochemical research to study its anti-inflammatory role in cellular signaling pathways and physiological processes. It is a key metabolite of dihomo-γ-linolenic acid (DGLA), generated via the 15-lipoxygenase pathway, and contributes to the regulation of eicosanoid production. These compounds are involved in modulating inflammation, immune responses, vascular tone, and pulmonary functions. It is employed as a research tool to investigate interactions with other lipid mediators and its effects on conditions such as asthma, atherosclerosis, rheumatoid arthritis, and other inflammatory diseases.