14,15-Leukotriene E4 is involved in inflammatory and immune responses, particularly in allergic conditions such as asthma and allergic rhinitis. It contributes to airway inflammation by promoting bronchoconstriction, increasing vascular permeability, and recruiting eosinophils and other immune cells to sites of inflammation. Due to its role in sustaining inflammatory processes, it serves as a biomarker for monitoring disease activity and response to therapy in chronic respiratory diseases. It also plays a part in modulating the activity of other inflammatory mediators, making it a target of interest in the development of anti-inflammatory and anti-allergic drugs.