(±)9(10)-DiHOME is a fatty acid diol metabolite derived from linoleic acid through cytochrome P450 or soluble epoxide hydrolase pathways. It plays a significant role in modulating immune and inflammatory responses. The compound has been studied for its ability to enhance T-cell migration and infiltration into tissues, particularly in tumor microenvironments, suggesting potential relevance in cancer immunology. It is also implicated in metabolic regulation, with studies linking elevated levels of (±)9(10)-DiHOME to insulin resistance and mitochondrial dysfunction in skeletal muscle and adipose tissue. This makes it a biomarker of interest in metabolic disorders such as obesity and type 2 diabetes. Additionally, (±)9(10)-DiHOME has been shown to influence cardiac function by modulating mitochondrial respiration and energy metabolism in cardiomyocytes, indicating possible involvement in cardiovascular diseases. Due to its biological activity in inflammation, metabolism, and immunity, (±)9(10)-DiHOME is used as a research tool to investigate pathophysiological mechanisms and as a potential target for therapeutic intervention.